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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Resveratrol, Sirolimus
Phytochemical Name Resveratrol (PubChem CID: 445154 )
Anticancer drug Name Sirolimus (PubChem CID: 5284616 )
Structure of
Phytochemical
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2D MOL 3D MOL
Structure of
Anticancer Drug
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Decreasing Drug Toxicity
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Combination Pair ID: 811
Pair Name Resveratrol, Sirolimus
Disease Info [ICD-11: 2F7C] Lymphangioleiomyomatosis Investigative
Gene Regulation Down-regulation Expression VEGFD KEGG ID N.A.
Result The addition of resveratrol was safe and well tolerated in patients with lymphangioleiomyomatosis receiving sirolimus and was associated with modest improvement in HRQOL. Larger controlled trials of this combination may be warranted to assess definitively the usefulness of resveratrol as an additive therapy in lymphangioleiomyomatosis.
03. Reference
No. Title Href
1 Safety and Efficacy of Combined Resveratrol and Sirolimus in Lymphangioleiomyomatosis. Chest. 2023;163(5):1144-1155. doi:10.1016/j.chest.2023.01.007. Click
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